Endocrine Abstracts

Background: Postprandial hypoglycemia is an increasingly recognized complication after bariatric surgery. Its hallmark is a pronounced glycemic rise after carbohydrate ingestion followed by an exaggerated hyperinsulinemic response. Recent studies have shown that IL-1β contributes to postprandial stimulation of insulin. Furthermore, inhibition of SGLT2 reduces excessive plasma glucose increase. Therefore, we investigated whether inhibition of IL-1β with the IL-1 recep...

Background: Higher testosterone levels during pregnancy in women with polycystic ovary syndrome (PCOS) could be associated with longer offspring ano-genital distance (AGD).Aims: To compare AGD between offspring of mothers with PCOS and controls and to determine possible associations between maternal 3rd trimester testosterone levels and offspring AGD at three months of age.Methods: The study was part of the prospective s...

Background: Hypogonadism is prevalent during opioid treatment, but the effect of testosterone replacement treatment (TRT) on body composition, pain perception, and adrenal function is unclear.Purpose: To measure changes in body composition, pain perception, quality of life and adrenal function after TRT or placebo in opioid treated men with chronic non-malignant pain.Methods: Double-blinded, placebo-controlled study in 41 men (&#62...

Context: Acromegaly is a rare and insidious disease associated with severe somatic morbidity but data on socioeconomic status are scarce.Objective: To study the socioeconomic status in acromegaly in a population based, nationwide follow-up study.Patients and Methods: All incident cases of acromegaly (n = 576) during the period 1997–2010 were included, representing 10.116 years at risk. For every patient, 100 pers...

Bispenol A (BPA) is a chemical often integrated in impact-resistant plastics and surface coatings in canned foods as well as screw-on caps and cashier receipts. BPA is either intentionally added or appear as a consequence of recycling in materials with food contact, which leaves consumers at risk of exposure. BPA has known endocrine disrupting effects and is suspected to be a contributing factor in disorders such as overweight, diabetes, cardiovascular diseases, and behavioral...

Background: Conventional glucocorticoid replacement therapies result in unphysiological variation in plasma cortisol levels; concern has been raised regarding long-term metabolic consequences. Glucocorticoid replacement is technically feasible by continuous subcutaneous hydrocortisone infusion (CSHI), which can mimic the normal diurnal cortisol rhythm. The aim of this study was to compare insulin sensitivity in patients with Addison’s disease (AD) on CSHI vs three daily d...

Introduction: Male hypogonadism is one of the most common endocrine disorders affecting 5.6% of men aged between 30–79 years. Testosterone deficiency (TD) is an independent risk factor for multiple cardiovascular risk factors including obesity, diabetes mellitus, hypertension, dyslipidaemia and endothelial dysfunction. The aims of testosterone replacement treatment (TRT) in hypogonadism are to improve or ameliorate the clinical features and to restore the serum T to physi...

Objective: To investigate the effect of pioglitazone on cortisol metabolism in PCOS.Design: Thirty insulin resistant PCOS patients were randomized to either 16 weeks of pioglitazone (30 mg/day) or placebo treatment. Before and after intervention, patients underwent 24 h 20 min.-integrated blood sampling for measurement of cortisol and 24 h excretion of cortisol, cortisone and steroid metabolites (cortisol, corticosteron, androgen, and 17-hydroxyprogester...

Background: Studies from different parts of the world have given controversial results regarding the association of transcription factor 7like 2 (TCF7L2) gene polymorphism with Type 2 diabetes mellitus (T2DM) and diabetic nephropathy (DN). Aim: This study aimed to investigate if TCF7L2 gene polymorphism, rs12255372(G>T) is a risk factor for the development of T2DM and DN in type 2 Egyptian diabetic patients. PATIENTS AND METHODS: This study was conducted ...

Women with COVID-19 and Long COVID (symptoms >4 weeks) have reported AUB. We investigated (i) the association between COVID-19/Long COVID and AUB and (ii) ovarian sex hormones across the menstrual cycle in women with Long COVID. Two studies were completed with ethical approvals and consent. Firstly, a retrospective online survey ‘The Covid-19 Pandemic and Women’s Reproductive Health’ was conducted March-May 2021 with UK participants >18 years old (n<...